Simple and scalable electrosynthesis of 1H-1-hydroxy-quinazolin-4-ones

Olesja Koleda, Tobias Prenzel, Johannes Winter, Tomoki Hirohata, Maria de Jesus Galvez-Vazquez, Dieter Schollmeyer, Shinsuke Inagi, Edgars Sūna, Siegfried R Waldvogel

1. General Information........................................................................................................ 2 2. General Protocols........................................................................................................... 6 2.1. General Protocol for the Synthesis of Substituted 2-Nitrobenzamides (GPI) ........... 6 2.2. General Protocol for the Synthesis of Substituted N-Acyl-2-nitrobenzamides (GPII) 6 2.3. General Protocol for the Synthesis of Methyl (2-nitrobenzoyl)carbamates (GPIII) ... 6 2.4. General Protocol for the Electrochemical Synthesis of Substituted 1H-1-Hydroxyquinazolin-4-ones (GPIV) .................................................................. 7 2.5. General Protocol for the Scale-Up of Electrochemical Synthesis of 6a (GPV) ......... 7 3. Optimisation of the Electrolytic Reaction Conditions ....................................................... 8 4. CV-Studies ..................................................................................................................... 9 5. Preparation of Products and Analytical Data .................................................................11 6. Crystallographic Data ....................................................................................................31 7. NMR Spectra.................................................................................................................33 8. References ..................................................................................................................108

Date
16.02.2023.
Keywords
Simple and scalable electrosynthesis of 1H-1-hydroxy-quinazolin-4-ones
Hyperlink
https://www.rsc.org/suppdata/d3/sc/d3sc00266g/d3sc00266g1.pdf