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Publikācija: Triazolylmethyl Aziridines with Various Side Chain

Publication Type Publication (anonimusly reviewed) in a journal with an international editorial board indexed in other databases
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Triazolylmethyl Aziridines with Various Side Chain
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Jānis Zemītis
Imants Kreituss
Māris Turks
Ērika Bizdēna
Peteris Trapencieris
Keywords triazolylmethyl aziridines, CuAAC reaction, deprotection
Abstract More than hundred compounds from aziridine class shown certain biological activity. We report here the synthesis of racemic version of protected azidomethyl aziridine via easily accessible intermediates. Further, small combinatorial library of triazolylmethyl aziridines was obtained by CuAAC reaction and deprotection. To the best of our knowledge such aziridine derivatives have not been tested for their biological activities. Comparison of synthesis of racemic and enantiomerically pure series of products and their biological activities will be discussed.
Reference Zemītis, J., Kreituss, I., Turks, M., Bizdēna, Ē., Trapencieris, P. Triazolylmethyl Aziridines with Various Side Chain. Latvijas Ķīmijas Žurnāls, 2012, Nr.1, pp.79-79. ISSN 0868-8249.
ID 12971