Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering

Riga Technical University 53rd International Scientific Conference: Dedicated to the 150th Anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni: Digest 2012
Jurijs Dehtjars, I. Khlusov, M. Khlusova, E. Gostichev, Yu. Sharkeev, V. Pichugin

Currently, a lot of publications, mainly as hypotheses, were dedicated to niches for hemopoietic stem cells (HSC). Multipotent mesenchymal stromal cells (MMSC) are treated as important cell component of HSC niches [1]. At the same time, the circumstance that discussion of existence of niches determining fate of MMSC themselves just appears in literature sets at gaze [2]. Pilot experimental data about existence and dimensions of niches for osteogenic differentiation of MMSC, their close dependence on quantitative variables of bone mineral substance relief were recently obtained by us [3]. In this connection, investigation of the relief features effects of model mineral matrix on structural-functional conditions of human MMSC and remodeling of bone/bone marrow system in mice was of great interest.

Keywords
niche-relief, niche-voltage, hematopoietic
Hyperlink
http://scientific-conference2012.rtu.lv/sites/default/files/RTU_Conference_2012.pdf

Dehtjars, J., Khlusov, I., Khlusova, M., Gostichev, E., Sharkeev, Y., Pichugin, V. Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering. In: Riga Technical University 53rd International Scientific Conference: Dedicated to the 150th Anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni: Digest, Latvia, Riga, 10-12 October, 2012. Riga: RTU, 2012, pp.642-642. ISBN 978-9934-10-360-5.

Publication language
English (en)