Evaluation of (E)-2-Chlorovinylsulfones as Novel Class of Cytotoxic Agents and Highly (E)-Stereoselective Addition of N-, S- And Se-Nucleophiles to (E)-2-Chlorovinylsulfones under Phase Transfer Catalysis Conditions
Heterocyclic Letters
2012
J. Višņevska,
Sergejs Beļakovs,
I. Shestakova,
A. Gulbe,
E. Jaschenko,
E. Ābele
Novel phase transfer catalytic (PTC) method for the conjugate addition-elimination of N-, S- and Se-nucleophiles to (E)-2-chlorovinylsulfones has been developed. Products were isolated in yields up to 98%. (E)-2-Chlorovinylsulfones exhibit very high cytotoxicity against MG-22A and HT-1080 cancer cell lines
Keywords
2-chlorovinylsulfones; conjugate addition; phase transfer catalytic system; toxicity; cytotoxicity
Hyperlink
http://www.heteroletters.org/issue7/pdf/paper-1.pdf
Višņevska, J., Beļakovs, S., Shestakova, I., Gulbe, A., Jaschenko, E., Ābele, E. Evaluation of (E)-2-Chlorovinylsulfones as Novel Class of Cytotoxic Agents and Highly (E)-Stereoselective Addition of N-, S- And Se-Nucleophiles to (E)-2-Chlorovinylsulfones under Phase Transfer Catalysis Conditions. Heterocyclic Letters, 2012, Vol. 2, No. 3, pp.245-252. ISSN 2231-3087. e-ISSN 2230-9632.
Publication language
English (en)