Synthesis of N6-Substituted-2-Triazolyl-Adenine Derivatives

XVth International Conference "Heterocycles in Bio-organic Chemistry" : Program and Abstract Book 2013
Irina Novosjolova, Ērika Bizdēna, Sergejs Beļakovs, Māris Turks

A novel class of 2,6-bis-triazolylpurine nucleosides were obtained from 2,6-diazido precursors via copper (I) catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. These intermediates appeared to be very reactive towards N-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. Thereby, 1,2,3-triazoles act as good leaving groups in regioselective nucleophilic aromatic substitution reactions.

Keywords
Purine nucleosides, bis-triazolyl derivatives
Hyperlink
http://www.bioheterocycles.eu/pictures/zinas/46.pdf

Novosjolova, I., Bizdēna, Ē., Beļakovs, S., Turks, M. Synthesis of N6-Substituted-2-Triazolyl-Adenine Derivatives. In: XVth International Conference "Heterocycles in Bio-organic Chemistry" : Program and Abstract Book, Latvia, Riga, 27-30 May, 2013. Riga: 2013, pp.96-96.

Publication language
English (en)