"Click" Approach to the Synthesis of 2,6-Bis(1,2,3-triazolyl)purine Deoxynucleosides

Material Science and Applied Chemistry: Scientific Journal of Riga Technical University. Vol.27: Materials of the 8th Paul Walden Symposium on Organic Chemistry 2013
Kristers Ozols, Ērika Bizdēna

Azide-alkyne 1,3-dipolar cycloaddition reaction (click reaction) has been found to be useful in nucleoside, nucleotide and oligonucleotide chemistry. In last years a number of 1,2,3-triazolylnucleoside derivatives have been synthesized and investigated, leading to discovery of substances with antiviral and anticancer activity, enzyme inhibitors, adenosine receptor agonists and antagonists.

Keywords
Purine nucleosides, Deoxyribonucleosides, "Click" reaction

Ozols, K., Bizdēna, Ē. "Click" Approach to the Synthesis of 2,6-Bis(1,2,3-triazolyl)purine Deoxynucleosides. In: Material Science and Applied Chemistry: Scientific Journal of Riga Technical University. Vol.27: Materials of the 8th Paul Walden Symposium on Organic Chemistry, Latvia, Rīga, 13-14 May, 2013. Rīga: RTU Press, 2013, pp.87-87. ISSN 1407-7353. e-ISSN 2255-8713.

Publication language
English (en)