The objectives and goals of the first national Latvian biobank project are to develop, build and utilize cutting edge tissue biobank and databasae in Latvia containing samples of common malignant tumours and elaborate a multifunctional easy to use biobank database system. 1655 patients with oncological and premalignant diseases were enrolled in the study. Biobank information systems run on the operating system MS Windows 7 Professional. Server runs on MS Server 2008 R2 Standard environment, MS Windows SQL Server 2008 R2 Standard served as a database management system. In total 1655 patients with oncological and premalignant diseases were enrolled in the study during the 2010-2012. Our database comprised a total of 1655 cases covering all types of frequent human malignancies: breast cancer (30.64%), gastric (22.78%), colorectal (15.52%), prostate (17.38%) and thyroid (13.78%). The novel biobank information database was developed which fulfils all major biobanking criteria and extends these. The advantages of novel biobank information system are easy entry, retrieval and storage of information. The first Latvian biobank including malignant disease, premalignant conditions and autoimmune disease was elaborated. The novel easy to use and reproducible biobank information database system was developed and adapted.