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Publikācija: A Synthetic Route to 2

Publication Type Article in a collection of scientific publications or a chapter in a monograph with ISBN or ISSN
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language A Synthetic Route to 2,6-Bis-triazolyl Purine Deoxynucleosides via Click Chemistry
Title Collection Symposium Series Volume 14
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Dace Cīrule
Kristers Ozols
Irina Novosjolova
Māris Turks
Ērika Bizdēna
Keywords purine nucleosides, bis-triazolyl derivatives, X-ray analysis
Abstract 3',5'-O-Protected 2,6-diazidopurine deoxynucleosides have been obtained in multistep synthesis either from deoxyguanosine or by direct glycosylation of diazidopurine sodium salt. In the latter case, X-ray analysis confirms b-configuration and diazido tautomeric form of the obtained glycosylated diazidopurine. In click reaction the series of 2,6-bis(4-substituted-1,2,3-triazol-1-yl)purine deoxynucleosides were synthesized.
Reference Cīrule, D., Ozols, K., Novosjolova, I., Turks, M., Bizdēna, Ē. A Synthetic Route to 2,6-Bis-triazolyl Purine Deoxynucleosides via Click Chemistry. In: Collection Symposium Series Volume 14. M.Hocek ed. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. pp.233-234. ISBN 978-80-86241-50-0.
ID 18344