Synthesis and Antiradical Properties of 4-Aryl-3,4-Dihydroquinolin-2(1H)-Ones – Aza-Analogues of Neoflavonoids

Химия гетероциклических соединений = Chemistry of Heterocyclic Compounds 2014
Inese Mieriņa, Agnese Stikute, Māra Jure

The convenient one-pot method for synthesis of 4-aryl-3,4-dihydroquinolin-2(1H)-ones starting from monoanilides of malonic acid and aromatic aldehydes is presented. The obtained 4-aryl-3,4-dihydroquinolin-2(1H)-ones have been tested for their antiradical activity (DPPH and GO tests). It was found, that the highest antiradical activity have derivatives of syringaldehyde; activity of other compounds was moderate or low, but in DPPH test it was comparable or higher than in the case of widely applied antioxidant BHT.

Keywords
4-Aryl-3,4-dihydroquinolin-2(1H)-one, 4-Aryl-2-oxo-1,2,3,4-tetrahydroquinoline, 4-Aryl-3,4-dihydrocarbostyryl, Monoanilide of malonic acid, Monoanilide of arylidenemalonic acid, Hydroarylation, Antioxidant, Anti-radical activity
Hyperlink
http://hgs.osi.lv/index.php/hgs/article/view/1593

Mieriņa, I., Stikute, A., Jure, M. Synthesis and Antiradical Properties of 4-Aryl-3,4-Dihydroquinolin-2(1H)-Ones – Aza-Analogues of Neoflavonoids. Химия гетероциклических соединений = Chemistry of Heterocyclic Compounds, 2014, No. 8, pp.1232-1242. ISSN 0132-6244.

Publication language
Russian (ru)