Synthetic Applications of 2,6-Diazidopurine Nucleosides Leading to Modified Triazolylpurine Derivatives

8th Biennial International Conference on Organic Synthesis "Balticum Organicum Syntheticum" (BOS 2014): Program and Abstract Book 2014
Irina Novosjolova, Dmitrijs Stepanovs, Ērika Bizdēna, Anatolijs Mišņovs, Māris Turks

Here we report the use of 2,6-diazidopurine nucleoside in the nucleophilic aromatic substitution reactions with different S-nucleophiles. The regioselectivity of these reactions depend on the nature of the S-nucleophile. When the SNAr reaction between the diazide and cyclohexanethiol was made, the C(2)-substitution product (R = c-Hex) was obtained. It exists as a mixture of two tautomeric forms.

Keywords
purine, deoxyribo-nucleosides, Click chemistry

Novosjolova, I., Stepanovs, D., Bizdēna, Ē., Mišņovs, A., Turks, M. Synthetic Applications of 2,6-Diazidopurine Nucleosides Leading to Modified Triazolylpurine Derivatives. In: 8th Biennial International Conference on Organic Synthesis "Balticum Organicum Syntheticum" (BOS 2014): Program and Abstract Book, Lithuania, Vilnius, 6-9 July, 2014. Vilnius: 2014, pp.110-110.

Publication language
English (en)