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Publikācija: 2

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language 2,6-Diazidopurine Deoxyribo-Nucleoside as Substrate for the Click Reaction
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Dace Cīrule
Kristers Ozols
Ērika Bizdēna
Irina Novosjolova
Keywords Deoxyribonucleosides, "Click" chemistry
Abstract The chemistry of triazolyl-substituted purine nucleosides is attractive since some of them exhibit antiviral, anticancer or fluorescent properties. Our group has reported the synthesis of 2,6-bistriazolyl purine arabino- and ribo-nucleosides using Cu(I) catalysed azide - alkyne 1,3-dipolar cycloaddition reaction. Various nucleophilic substitution reactions with the obtained products were carried out. In addition to our previous work, herein we report the synthesis of the novel bis-triazolyl purine deoxyribo-nucleosides and their reactions with N- nucleophiles.
Reference Cīrule, D., Ozols, K., Bizdēna, Ē., Novosjolova, I. 2,6-Diazidopurine Deoxyribo-Nucleoside as Substrate for the Click Reaction. In: Abstracts of Riga Technical University 55th International Scientific Conference : Section: Material Science and Applied Chemistry, Latvia, Rīga, 14-17 October, 2014. Rīga: 2014, pp.19-19.
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ID 19040