Synthesis of Novel Quinazolinone-1,2,3-Triazole Conjugates

Journal of Chemical and Pharmaceutical Research 2014
Gerda Krastiņa, Irisa Rāviņa, Inese Mieriņa, Daina Zicāne, Māris Turks, Zenta Tetere, Ainārs Leončiks

Hybrid compounds of 2-styryl quinazolinone and 1,2,3-triazoles were synthesized via 1,3-dipolar azide-alkyne cycloaddition reaction from 3-(2-azidoethyl)quinazolinones and various alkynes, followed by Knoevenagel reaction between 2-methylquinazolinone-1,2,3-triazole conjugates and aromatic aldehydes. All quinazolinone-1,2,3-triazole hybrid compounds were tested for their antiradical and antibacterial activity, but did not show any significant activity.

Keywords
2-Styryl quinazolinone-1,2,3-triazole conjugate, Huisgen reaction, Knoevenagel condition, antiradical activity, antibacterial activity
Hyperlink
http://jocpr.com/vol6-iss12-2014/JCPR-2014-6-12-6-14.pdf

Krastiņa, G., Rāviņa, I., Mieriņa, I., Zicāne, D., Turks, M., Tetere, Z., Leončiks, A. Synthesis of Novel Quinazolinone-1,2,3-Triazole Conjugates. Journal of Chemical and Pharmaceutical Research, 2014, Vol. 6, No. 12, pp.6-14. ISSN 0975-7384.

Publication language
English (en)