Application of the Ireland-Claisen Rearrangement in the Total Syntheses of Natural Products

2015
Gints Šmits

Defending
28.05.2015. 14:00, Materiālzinātnes un lietišķās ķīmijas fakultātē, Paula Valdena ielā 3, 272. auditorijā.

Supervisor
Ronalds Zemribo

Reviewers
Māris Turks, Edgars Sūna, Peteris Trapencieris

The thesis focuses on application of the Ireland-Claisen rearrangement towards the total synthesis of natural products. Ireland-Claisen rearrangement of 6-methylene-1,4-oxazepan-2-one and 7-methylene-1,5-oxazocan-2-one was investigeted. Total syntheses of barmumycin, Limazepine E and 8-deoxypumiliotoxine 193H were accomplished. The crucial building block necessary for the total synthesis of eleganine A was obtained and studies towards the total synthesis of lucentamycins were performed.

Keywords
Ireland-Claisen rearrangement

Šmits, Gints. Application of the Ireland-Claisen Rearrangement in the Total Syntheses of Natural Products. PhD Thesis. Rīga: [RTU], 2015. 173 p.

Publication language
Latvian (lv)