The Role of Carboxylic Group Position on the Antiradical Activity of Synthetic Analogues of Oat Antioxidants

Journal of Chemical and Pharmaceutical Research 2015
Inese Mieriņa, Mazena Zaharova, Māra Jure, Ilze Māliņa

The aim of our research was to establish structure-antiradical activity relationships of the synthetic analogues of naturally occurring antioxidants - avenanthramides. We studied the influence of the position of carboxylic group in aniline moiety and substituents in the cinnamic acid moiety. It was found out that the position of carboxylic group did not have any significant impact on the antiradical activity of compounds in DPPH test; opposite situation was observed in case of feruloyl anilines in GO assay.

Keywords
Avenanthramides, N-cinnamoyl anilines, antiradical activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl (GO)
Hyperlink
http://jocpr.com/vol7-iss6-2015/JCPR-2015-7-6-416-427.pdf

Mieriņa, I., Zaharova, M., Jure, M., Māliņa, I. The Role of Carboxylic Group Position on the Antiradical Activity of Synthetic Analogues of Oat Antioxidants. Journal of Chemical and Pharmaceutical Research, 2015, Vol. 7, No. 6, pp.416-427. ISSN 0975-7384.

Publication language
English (en)