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Publikācija: Bistriazolylpurine Deoxyribonucleosides: Synthesis and Reactions

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Bistriazolylpurine Deoxyribonucleosides: Synthesis and Reactions
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Research platform Materials, Processes, and Technologies
Authors Dace Cīrule
Kristers Ozols
Ilze Māliņa
Ērika Bizdēna
Keywords "Click" chemistry, Fluorescent nucleosides, Heteroaromatic substitution
Abstract In last years a number of 1,2,3-triazolylnucleoside derivatives have been synthesized and investigated, leading to discovery of substances with antiviral and anticancer activity, enzyme inhibitors, adenosine receptor agonists and antagonists. Our group has reported the synthesis of 2,6-bistriazolyl purine arabino- and ribonucleosides in Cu(I)-promoted azide-alkyne cycloaddition reactions. The reactivity of products towards nucleophilic species has also been discussed. In addition to our previous work, herein we report the synthesis of the novel bistriazolylpurine deoxyribonucleosides and their reactions with N- and S-nucleophiles.
Reference Cīrule, D., Ozols, K., Māliņa, I., Bizdēna, Ē. Bistriazolylpurine Deoxyribonucleosides: Synthesis and Reactions. In: Drug Discovery Conference: Abstract Book, Latvia, Rīga, 27-29 August, 2015. Rīga: 2015, pp.93-93.
ID 20666