Synthesis and Fluorescence Properties of 2-Methylamino-6-triazolylpurine Deoxyribonucleoside

Abstracts of the Riga Technical University 56th International Scientific Conference 2015
Kristers Ozols, Dace Cīrule, Irina Novosjolova

The fluorescent nucleoside isomorphs are tools used for the exploration of structure and interactions of nucleic acids. For instance, they are employed in single-nucleotide polymorphysm assays and for the investigation of interactions between nucleic acids and drugs. Recently, a method for the synthesis of nucleoside analogues possessing fluorescent properties was reported by our group. This approach is used in the present research for the synthesis of a novel compound. Its fluorescent properties have shortly been examined leading to interesting results.

Keywords
2,6-diazidopurine, fluorescent nucleoside analogues, azide-alkyne cycloaddition, fluorescent oligonucleotides

Ozols, K., Cīrule, D., Novosjolova, I. Synthesis and Fluorescence Properties of 2-Methylamino-6-triazolylpurine Deoxyribonucleoside. In: Abstracts of the Riga Technical University 56th International Scientific Conference, Latvia, Riga, 14-16 October, 2015. Riga: RTU Press, 2015, pp.11-11.

Publication language
English (en)