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Publikācija: A Synthetic Route for C6-Derivatization of Purine Deoxyribonucleosides

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language A Synthetic Route for C6-Derivatization of Purine Deoxyribonucleosides
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Dace Cīrule
Kristers Ozols
Ilze Māliņa
Irina Novosjolova
Ērika Bizdēna
Keywords 2,6-diazidopurine, 2’-deoxyribonucleosides, azide-alkyne cycloaddition, triazoles, nucleophilic substitution reaction
Abstract In last years a number of 1,2,3-triazolylnucleoside derivatives have been synthesized and investigated, leading to discovery of substances with antiviral and anticancer activity, enzyme inhibitors, adenosine receptor agonists and antagonists. Our group has reported the synthesis of 2,6-bistriazolyl purine arabino- and ribonucleosides in Cu(I)-promoted azide-alkyne cycloaddition reactions. The reactivity of products towards nucleophilic species has also been discussed. In addition to our previous work, herein we report the synthesis of the novel bistriazolylpurine deoxyribo-nucleosides and their reactions with N- and S nucleophiles.
Reference Cīrule, D., Ozols, K., Māliņa, I., Novosjolova, I., Bizdēna, Ē. A Synthetic Route for C6-Derivatization of Purine Deoxyribonucleosides. In: Abstracts of the Riga Technical University 56th International Scientific Conference, Latvia, Riga, 14-16 October, 2015. Riga: RTU Press, 2015, pp.12-12.
ID 20932