Stereoselective Synthesis of the Diazonamide a Macrocyclic Core

Journal of Organic Chemistry 2015
Ilga Mutule, Beomjun Joo, Zane Medne, Toms Kalniņš, Edwin Vedējs, Edgars Sūna

Stereoselective synthesis of the right-hand heteroarom. macrocycle of diazonamide A features C16-C18 bond formation in the Suzuki-Miyaura cross-coupling and atropodiastereoselective Dieckmann-type macrocyclization as key steps. The Suzuki-Miyaura cross-coupling gave the best yields when it was catalyzed by a palladium-dioxygen complex.

Keywords
Stereoselective Synthesis of the Diazonamide A Macrocyclic Core
DOI
10.1021/jo5029419
Hyperlink
http://pubs.acs.org/doi/abs/10.1021/jo5029419

Mutule, I., Joo, B., Medne, Z., Kalniņš, T., Vedējs, E., Sūna, E. Stereoselective Synthesis of the Diazonamide a Macrocyclic Core. Journal of Organic Chemistry, 2015, Vol.80, Iss.6, pp.3058-3066. ISSN 0022-3263. e-ISSN 1520-6904. Available from: doi:10.1021/jo5029419

Publication language
English (en)