One-Step Preparation of Pyrrolo[1,4]benzodiazepine Dilactams: Total Synthesis of Oxoprothracarcin, Boseongazepines B and C

Synlett 2015
Gints Šmits, Rolands Zemribo

A one-step synthesis of pyrrolo[1,4]benzodiazepine dilactams has been developed. The high yielding method involves direct coupling of unprotected anthranilic acids with proline esters. This transformation was successfully applied in the first total syntheses of boseongazepines B and C as well as oxoprothracarcin and limazepine E.

Keywords
boseongazepine | dilactams | oxoprothracarcin | pyrrolo[1,4]benzodiazepine | total synthesis
DOI
10.1055/s-0034-1378877
Hyperlink
https://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1378877

Šmits, G., Zemribo, R. One-Step Preparation of Pyrrolo[1,4]benzodiazepine Dilactams: Total Synthesis of Oxoprothracarcin, Boseongazepines B and C. Synlett, 2015, Vol.26, Iss.16, pp.2272-2276. ISSN 0936-5214. Available from: doi:10.1055/s-0034-1378877

Publication language
English (en)