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Publikācija: Novel Lupane Triterpenoid-Indazole Conjugates with Oxime Linkage

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Novel Lupane Triterpenoid-Indazole Conjugates with Oxime Linkage
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Daina Zicāne
Zenta Tetere
Irisa Rāviņa
Tatyana S. Khlebnicova
Yuri A. Piven
Fedor A. Lakhvich
Viktors Kumpiņš
Inese Rijkure
Inese Mieriņa
Uldis Peipiņš
Svetlana V. Shishkina
Māris Turks
Keywords triterpenoid-indazole conjugates oxime linkage
Abstract Betulin 1 and its derivatives demonstrate wide range of biological activity. On the other hand indazole skeleton and oxime linkage are attractive, pharmaceutically active structural scaffolds in medicinal chemistry. Thus, introduction of indazole skeleton and oxime functionality into the structure of betulin is reasonable approach to potential cytotoxic agents. Synthesis of the target compounds 2 was started with oxidation of betulin 1. The obtained betulonic acid 3 was successfully purified through formation of its cyclohexylammonium salt. Lupane triterpenoidindazole hybrids 2 with oxime linkage were obtained from betulonic acid chloride 4 and corresponding oximes 5 with medium to high yields.
Hyperlink: http://www.boschem.eu/public/BOS2016/BOS-2016_Anstract-Book_Final.pdf 
Reference Zicāne, D., Tetere, Z., Rāviņa, I., Khlebnicova, T., Piven, Y., Lakhvich, F., Kumpiņš, V., Rijkure, I., Mieriņa, I., Peipiņš, U., Shishkina, S., Turks, M. Novel Lupane Triterpenoid-Indazole Conjugates with Oxime Linkage. In: Balticum Organicum Syntheticum: Program and Abstracts, Latvia, Riga, 3-6 July, 2016. Riga: 2016, pp.180-180.
ID 22434