Synthesis of New Aziridine and Azetidine Derivatives as Potential MMP-2 Inhibitors

Balticum Organicum Syntheticum: Program and Abstracts 2016
Krista Gulbe, Diāna Stamberga, Andrejs Solops, Ilona Domracheva, Māris Turks

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for cleavage of extracellular matrix proteins. Because of their effect on both physiological and pathological processes, MMPs, especially MMP-2, have become interesting targets for treatment of cancer. Herein we report potency of MMP-2 inhibition among aziridine and azetidine derivatives containing 1,4- or 1,5- disubstituted triazoles in the side chain.

Keywords
MMP inhibitors, CuAAC, RuAAC
Hyperlink
http://www.boschem.eu/public/BOS2016/BOS-2016_Anstract-Book_Final.pdf

Suta, K., Stamberga, D., Solops, A., Domracheva, I., Turks, M. Synthesis of New Aziridine and Azetidine Derivatives as Potential MMP-2 Inhibitors. In: Balticum Organicum Syntheticum: Program and Abstracts, Latvia, Riga, 3-6 July, 2016. Riga: 2016, pp.156-156.

Publication language
English (en)