Synthetic Approaches to 4-(Het)Aryl-3,4-Dihydroquinolin-2(1H)-Ones

Химия гетероциклических соединений = Chemistry of Heterocyclic Compounds 2016
Inese Mieriņa, Māra Jure, Agnese Stikute

This review summarizes strategies for the synthesis of 4-(het)aryl-3,4-dihydroquinolin-2(1H)-ones which are of interest due to their biological activity. It covers methods elaborated particularly for obtaining the title heterocycles, as well as procedures where these compounds are formed as side products. 4-Aryl-3,4-dihydroquinolin-2(1H)-one derivatives have been used for the synthesis of valuable molecules, e.g,. anticancer drug tipifarnib.

Keywords
4-(het)aryl-3,4-dihydroquinolin-2(1H)-ones; lactams; nitrogen heterocycles; multicomponent reactions; Friedel–Crafts reactions
Hyperlink
http://hgs.osi.lv/index.php/hgs/article/view/3320

Mieriņa, I., Jure, M., Stikute, A. Synthetic Approaches to 4-(Het)Aryl-3,4-Dihydroquinolin-2(1H)-Ones. Химия гетероциклических соединений = Chemistry of Heterocyclic Compounds, 2016, Vol.52, No.8, pp.509-523. ISSN 0132-6244.

Publication language
English (en)