Spreading of Tissue Spheroids from Primary Human Fibro Blasts on the Surface of Microfibrous Electrospun Polyurethane Matrix

Морфология 2015
Е.В. Кудан, Е.А. Буланова, Ф.Д.А.С. Перейра, В.A. Парфенов, Vladimirs Kasjanovs, Ю.Д. Хесуани, В.А. Миронов

Tissue spheroids biofabricated from primary human fibroblasts using non-adhesive agarose forms, were placed by 3D bioprinter on the surface of microfibrous electrospun matrix. It was demonstrated that tissue spheroids attached to the surface of matrix during several hours and then gradually spread for several days which indicates high level of biocompatibiity of electrospun microfibrous polyurethane matrix. During this activity, human fibroblasts used processes of leading cell borders for initial step of attachment to matrix filaments. Tissue constructions formed during spreading of tissue spheroids on the surface of electrospun microfibrous polyurethane matrix seem to be a perspective technology platform for development of new methods of biofabrication and 3D bioprinting.

Keywords
тканевые сфероиды, внеклеточный матрикс, распластывание, биосовместимость
Hyperlink
https://www.elibrary.ru/item.asp?id=25010983

Кудан, Е., Буланова, Е., Перейра, Ф., Парфенов, В., Kasjanovs, V., Хесуани, Ю., Миронов, В. Spreading of Tissue Spheroids from Primary Human Fibro Blasts on the Surface of Microfibrous Electrospun Polyurethane Matrix. Морфология, 2015, Vol. 148, No. 6, pp.70-74. ISSN 1026-3543.

Publication language
Russian (ru)