Synthesis of 6-Sulfamoylsaccharin and Study of Its Reactivity in Alkylation Reactions

Chemistry of Heterocyclic Compounds 2012
Jekaterīna Ivanova, Raivis Žalubovskis, Eriks Simins, Igor Vozny, Peteris Trapencieris

An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzo-thiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occurs regioselectively at the isothiazoline ring nitrogen atom. © 2012 Springer Science+Business Media, Inc.

Keywords
6-sulfamoylsaccharin | alkylation | benzylation | oxidative cyclization | regioselectivity
DOI
10.1007/s10593-012-0948-8
Hyperlink
http://link.springer.com/article/10.1007%2Fs10593-012-0948-8

Ivanova, J., Žalubovskis, R., Simins, E., Vozny, I., Trapencieris, P. Synthesis of 6-Sulfamoylsaccharin and Study of Its Reactivity in Alkylation Reactions. Chemistry of Heterocyclic Compounds, 2012, Vol.47, Iss.12, pp.1561-1564. ISSN 0009-3122. Available from: doi:10.1007/s10593-012-0948-8

Publication language
English (en)