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Publikācija: Novel Method for the Preparation of 2h-1

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Novel Method for the Preparation of 2h-1,2,4-Benzothiadiazin-3(4h)-One 1,1-Dioxides via a Curtius Rearrangement
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Jekaterīna Ivanova
Raivis Žalubovskis
Igor Vozny
Peteris Trapencieris
Diana Borovika
Keywords 2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide | Acylazide | Curtius rearrangement | Hydrazide | Intramolecular cyclization | Saccharin
Abstract 1,2,4-Benzothiadiazines are known for their antiviral activity, hence work on their synthesis has been carried out for quite some time. Hence in the study it was shown that a series of 1,2,4-benzo-thiadiazinones could be prepared by the reaction of anilines with chlorosulfonyl isocyanate and cyclization of the N-chlorosulfonyl ureas. More recently the palladium-catalyzed cyclocarbonylation of o-aminobenzenesulfon-amides has been reported. We have developed a novel method for the preparation of the 2H-1,2,4-benzo-thiadiazin-3(4H)-one 1,1-dioxides from saccharin derivatives, the key stage of which is a Curtius rearrangement followed by an intramolecular cyclization.
DOI: 10.1007/s10593-012-1108-x
Hyperlink: http://link.springer.com/article/10.1007%2Fs10593-012-1108-x 
Reference Ivanova, J., Žalubovskis, R., Vozny, I., Trapencieris, P., Borovika, D. Novel Method for the Preparation of 2h-1,2,4-Benzothiadiazin-3(4h)-One 1,1-Dioxides via a Curtius Rearrangement. Chemistry of Heterocyclic Compounds, 2012, Vol.48, Iss.7, pp.1114-1116. ISSN 0009-3122. Available from: doi:10.1007/s10593-012-1108-x
Additional information Citation count:
ID 24032