The photoacoustic spectroscopy (PAS) has many applications in different fields of research and industry. PA spectroscopy is a form of spectroscopy, which uses both - light and sound and is based on the absorption of electromagnetic radiation by analyte molecules. In 1997, Rehman and Bonfield were the first to study the structure of carbonated apatite with the FTIR-PAS with the MTech PAS cell. They concluded that PAS provides a sensitive, nondestructive and fast means of analyzing synthesized hydroxyapatite and carbonated apatites. The aim of this study is to find advantages of PA spectroscopy with cantilever detector for the investigation of synthetic nanosized calcium apatite (in powder and on the pellet surface) and in archaeological human bone.