Search for Selective MMP 2 Inhibitors in Series of Novel Triazolylmethyl Aziridines and Azetidines

20th European Symposium on Organic Chemistry (ESOC 2017): Program. Section: Medicinal Chemistry and Chemical Biology 2017
Krista Gulbe, Diāna Stamberga, Andrejs Solops, Ilona Domracheva, Māris Turks

We have previously reported promising results for aziridine derivatives with 1,4 disubstituted 1,2,3 triazole in the side chain as a new class of MMP-2 inhibitors. Hence, we describe here an expansion of aziridine series by preparing both 1,5 and 1,4-disubstituted 1,2,3-triazole derivatives. Also azetidine-triazole conjugates were prepared.

Keywords
MMP-2 inhibitors, CuAAC, RuAAC

Suta, K., Stamberga, D., Solops, A., Domracheva, I., Turks, M. Search for Selective MMP 2 Inhibitors in Series of Novel Triazolylmethyl Aziridines and Azetidines. In: 20th European Symposium on Organic Chemistry (ESOC 2017): Program. Section: Medicinal Chemistry and Chemical Biology, Germany, Cologne, 2-6 July, 2017. online: 2017, pp.1-1.

Publication language
English (en)