Suspension bridge with prestressed cable truss and deck from cross-laminated timber panels was considered as an object of investigation. Prestressed cable truss with coincident in the centre point of the span main and stabilization cables and vertical suspenders only, was considered as the main load carrying system in considered structure of suspension bridge. Influence of cross-laminated timber deck on the behaviour of prestressed cable truss was evaluated by two physical and one numerical model. Two physical models of the structure with the span equal to 2 m were developed for checking of numerically obtained results and verification of numerical model. The first physical model was developed for the case, when panels of the deck are placed without clearances and develop arch- type structure in the direction of the span of prestressed cable trusses. The second physical model was developed for the case, when panels of the deck are placed with clearances and are working in the direction, which is perpendicular to the span of prestressed cable trusses only. The numerical model was developed by the programme ANSYS 12. The dependences of maximum vertical displacements and support reaction of the cable truss from the intensity of vertical load in cases of symmetric and unsymmetrical loading were obtained for the both physical models. Possibility to decrease by 20% the cable truss materials consumption by taking in to account combined work of prestressed cable trusses and cross-laminated timber panels was stated.