Synthesis and Evaluation of the Antibacterial, Antioxidant Activities of Novel Functionalized Thiazole and Bis(Thiazol-5-Yl)Methane Derivatives

Arkivoc 2018
I. Parasotas, K. Anusevicius, R. Vaickelioniene, I. Jonuskiene, M. Stasevych, V. Zvarych, K.-P. Olena, V. Novikov, Sergejs Beļakovs, V. Mickevicius

Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4- hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding α-halocarbonyl compounds in good yields. A series of chemical transformations of the obtained products were carried out, and new functionalized thiazole derivatives with aliphatic, aromatic and heterocyclic substituents were synthesized. 4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles were used as precursors for the synthesis of bis(thiazol-5-yl)methane derivatives, which then were screened for their antibacterial, antioxidant activities.

Keywords
antibacterial, antioxidant activities, thiazole, bis(thiazol-5-yl)methane derivatives
DOI
10.24820/ark.5550190.p010.159
Hyperlink
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.159

Parasotas, I., Anusevicius, K., Vaickelioniene, R., Jonuskiene, I., Stasevych, M., Zvarych, V., Olena, K., Novikov, V., Beļakovs, S., Mickevicius, V. Synthesis and Evaluation of the Antibacterial, Antioxidant Activities of Novel Functionalized Thiazole and Bis(Thiazol-5-Yl)Methane Derivatives. Arkivoc, 2018, Vol.2018, Part III, pp.240-256. ISSN 1551-7004. e-ISSN 1551-7012. Available from: doi:10.24820/ark.5550190.p010.159

Publication language
English (en)