Novel Hydrogels and Composite Hydrogels Based on ԑ-Polylysine, Hyaluronic Acid, and Hydroxyapatite

Key Engineering Materials. Vol.850: Materials Science and Applied Chemistry III: Selected peer-reviewed papers from 60th International Scientific Conference of Riga Technical University (RTU). Section of Materials Science and Applied Chemistry (MSAC 2019). 2020
Artemijs Ščeglovs, Kristīne Šalma-Ancāne

At this work, hydrogel and composite hydrogel systems based on ԑ-polylysine (EPL), hyaluronic acid (HA), and nanocrystalline hydroxyapatite (nHAp) were synthesized via chemical cross-linking method followed by in situ precipitation of nHAp into hydrogel copolymer matrix. Molecular structure, phase composition and morphology of EPL-HA and EPL-HA/nHAp systems were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray powder diffractometry (XRD), and scanning electron microscopy (SEM). The fabricated hydrogels and composite hydrogels were evaluated by measuring their gel fraction and swelling behavior. This study provides insights into developing cutting-edge bioactive hydrogels and composite hydrogels for bone tissue engineering as injectable biomaterials, where all system components have beneficial properties.

Keywords
Hydrogels, composite hydrogels, ԑ-polylysine, hyaluronic acid, hydroxyapatite, chemical cross-linking.
DOI
10.4028/www.scientific.net/KEM.850.242
Hyperlink
https://www.scientific.net/KEM.850.242

Ščeglovs, A., Šalma-Ancāne, K. Novel Hydrogels and Composite Hydrogels Based on ԑ-Polylysine, Hyaluronic Acid, and Hydroxyapatite. Key Engineering Materials, 2020, Vol. 850, pp.242-248. ISSN 1013-9826. e-ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.850.242

Publication language
English (en)