Aliphatic Chain-Containing Macrocycles as Diazonamide A Analogs
Chemistry of Heterocyclic Compounds 2020
Viktorija Vitkovska, Rimants Žogota, Toms Kalniņs, Diāna Zeļencova-Gopejenko, Edgars Sūna

[Figure not available: see fulltext.] Aliphatic alkyl chain-containing 12–14-membered macrocycles have been designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.


Keywords
anticancer agents, diazonamide A, macrocycles, ring-closing metathesis
DOI
10.1007/s10593-020-02704-6
Hyperlink
https://link-springer-com.resursi.rtu.lv/article/10.1007%2Fs10593-020-02704-6

Vitkovska, V., Žogota, R., Kalniņs, T., Zeļencova, D., Sūna, E. Aliphatic Chain-Containing Macrocycles as Diazonamide A Analogs. Chemistry of Heterocyclic Compounds, 2020, Vol. 56, No. 5, pp.586-602. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-020-02704-6

Publication language
English (en)
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