First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J

ACS Omega 2020
Juris Pelss, Gints Šmits

The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four-and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines.

DOI
10.1021/acsomega.0c01672
Hyperlink
https://pubs.acs.org/doi/10.1021/acsomega.0c01672

Pelss, J., Šmits, G. First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J. ACS Omega, 2020, Vol. 5, No. 21, pp.12568-12572. ISSN 2470-1343. Available from: doi:10.1021/acsomega.0c01672

Publication language
English (en)