Autofluorescence Imaging for Recurrence Detection in Skin Cancer Postoperative Scars
Journal of Biophotonics 2020
Mindaugas Tamošiūnas, Emīlija Vija Ploriņa, Marta Laņģe, Aleksandrs Derjabo, Ilona Kuzmina, Dmitrijs Bļizņuks, Jānis Spīgulis

This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non-melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check-ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence-based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development.


Keywords
autofluorescence imaging, recurrence, scar, skin cancer, surgery
DOI
10.1002/jbio.201900162
Hyperlink
https://onlinelibrary.wiley.com/doi/full/10.1002/jbio.201900162

Tamošiūnas, M., Ploriņa, E., Laņģe, M., Derjabo, A., Kuzmina, I., Bļizņuks, D., Spīgulis, J. Autofluorescence Imaging for Recurrence Detection in Skin Cancer Postoperative Scars. Journal of Biophotonics, 2020, Vol. 13, No. 3, Article number: e201900162. ISSN 1864-063X. e-ISSN 1864-0648. Available from: doi:10.1002/jbio.201900162

Publication language
English (en)
The Scientific Library of the Riga Technical University.
E-mail: uzzinas@rtu.lv; Phone: +371 28399196