Isolation, Chemistry, and Biology of Pyrrolo[1,4]Benzodiazepine Natural Products

Medicinal Research Reviews 2022
Guna Sakaine, A Ture, J Pedroni, Gints Šmits

The isolation of the antitumor antibiotic anthramycin in the 1960s prompted extensive research into pyrrolo[1,4]benzodiazepines (PBD) as potential therapeutics for the treatment of cancers. Since then, nearly 60 PBD natural products have been isolated and evaluated with regard to their biological activity. Synthetic studies and total syntheses have enabled access to PBD analogues, culminating in the development of highly potent anticancer agents. This review provides a summary of the occurrence and biological activity of PBD natural products and covers the strategies employed for their total syntheses.

Keywords
natural products | pyrrolo[1,4]benzodiazepines | total synthesis
DOI
10.1002/med.21803
Hyperlink
https://onlinelibrary.wiley.com/doi/10.1002/med.21803

Sakaine, G., Ture, A., Pedroni, J., Šmits, G. Isolation, Chemistry, and Biology of Pyrrolo[1,4]Benzodiazepine Natural Products. Medicinal Research Reviews, 2022, Vol. 42, No. 1, pp.5-55. ISSN 0198-6325. e-ISSN 1098-1128. Available from: doi:10.1002/med.21803

Publication language
English (en)