Synthetic Approach toward Enantiopure Cyclic Sulfinamides

Organic Letters 2022
Glebs Jersovs, Matiss Bojars, Pavel A. Donets, Edgars Sūna

A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral SVIderivatives such as sulfoximines and sulfonimidamides is demonstrated. 2022 The Authors.

Keywords
Tert-Butanesulfinyl Imines, Stereodivergent Synthesis, Asymmetric-Synthesis, Cycloaddition, Sulfoximines, Reduction, Ligands
DOI
10.1021/acs.orglett.2c01738
Hyperlink
https://pubs.acs.org/doi/10.1021/acs.orglett.2c01738

Jersovs, G., Bojars, M., Donets, P., Sūna, E. Synthetic Approach toward Enantiopure Cyclic Sulfinamides. Organic Letters, 2022, Vol. 24, No. 25, pp.4625-4629. ISSN 1523-7060. Available from: doi:10.1021/acs.orglett.2c01738

Publication language
English (en)