Copper-Catalyzed 1,3-Difunctionalization of Propargyl Silanes with Diaryliodanes and an Internal Nucleophile
Tetrahedron Symposium 2024 2024
Armands Sebris, Rūdolfs Beļaunieks, Māris Turks

Recently we have published preparative methods of propargyl silane 1,3-difunctionalization with concomitant silyl shift. The mechanistic concept involves propargylsilane activation with an appropriate electrophile, at which point silyl group undergoes 1,2-silyl shift. This creates an electrophilic carbon center that can react with a nucleophile. Previously examined electrophiles for propargyl silane activation are proton, electrophilic halogens and selenium. Both intramolecular and intermolecular nucleophiles are viable for attacking the electrophilic carbon center.


Keywords
Propargylsilane, diaryliodane, difunctionalization

Sebris, A., Beļaunieks, R., Turks, M. Copper-Catalyzed 1,3-Difunctionalization of Propargyl Silanes with Diaryliodanes and an Internal Nucleophile. In: Tetrahedron Symposium 2024, France, Montpellier, 18-21 June, 2024. Montpellier: 2024, pp.1-1.

Publication language
English (en)
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