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Publikācija: Synthesis of Novel (1-aziridinyl-1-hydroxyiminomethyl)Arenes and Their Citotoxic Activity

Publication Type Publication (anonimusly reviewed) in a journal with an international editorial board indexed in other databases
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Synthesis of Novel (1-aziridinyl-1-hydroxyiminomethyl)Arenes and Their Citotoxic Activity
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Anna Grigorjeva
Ivars Kalvinsh
Aigars Jirgensons
Ilona Dombracova
Elīna Jaščenko
Irina Šestakova
Viktors Andreanovs
Keywords амидоксимы, оксиимидоилхлориды, оксимы, азиридин, цитотоксическая активность.
Abstract The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC50 and LD50 values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl]benzoate, 1-aziridinyl(2-naphthyl)-methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.
DOI: 10.1007/s10593-009-0245-3
Hyperlink: http://link.springer.com/article/10.1007/s10593-009-0245-3 
Reference Grigorjeva, A., Kalvinsh, I., Jirgensons, A., Dombracova, I., Jaščenko, E., Shestakova, I., Andreanovs, V. Synthesis of Novel (1-aziridinyl-1-hydroxyiminomethyl)Arenes and Their Citotoxic Activity. Chemistry of Heterocyclic Compounds, 2009, Vol.49, Iss.2, pp.203-213. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-009-0245-3
ID 6520