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Publikācija: Development of Porous Calcium Phosphate Bone Scaffolds for Drug Delivery

Publication Type Publication (anonimusly reviewed) in a journal with an international editorial board indexed in other databases
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Development of Porous Calcium Phosphate Bone Scaffolds for Drug Delivery
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Research platform None
Authors Dagnija Loča
Jānis Ločs
Kristīne Šalma-Ancāne
Līga Bērziņa-Cimdiņa
Vita Zālīte
Daina Vempere
Keywords bioceramics, bone scaffolds, drug delivery systems, calcium phosphate ceramics
Abstract Synthetic calcium phosphates (CaP) are widely used as bone scaffolds due to their biocompatibility and osteoconductive properties. To be used as drug delivery systems, the pore structure of the scaffolds needs to be controlled in terms of porosity, pore size and pore interconnectivity. In this research hydroxyapatite/β-tricalcium phosphate biphasic mixture was synthesized by wet precipitation reaction. Porous bioceramics was obtained using highly viscous/plastic mass foaming, where polyol was used as a liquid phase for the mass preparation and H4NHCO3 was used as a pore forming agent. Porous ceramics obtained had the total porosity in range from 30 to 70 %. Gentamicin in porous bioceramic scaffolds was incorporated using vacuum infiltration. Results obtained demonstrated pore sizes in range from 60µm to 300µm in diameter, interconnectivity of pores, relatively dense pore walls and drug release within more than 6 hours.
Reference Loča, D., Ločs, J., Šalma-Ancāne, K., Bērziņa-Cimdiņa, L., Zālīte, V., Vempere, D. Development of Porous Calcium Phosphate Bone Scaffolds for Drug Delivery. Ceramics, 2010, Vol. 23, No. 2, pp.33-36.
ID 9396