Lysozyme (muramidase) is a well known antibacterial biopolymer which can be used in pharmaceutical and food technology. Synthesized carboxylic ion-exchanger on the base of acrylic monomers was used in experiments for lysozyme sorption study from model solutions. Ionization of ion-exchanger functional groups was studied by potentiometric titration in 0.1 M and 1.0 M NaCl solution. The results were correlated with the influence of solution ionic strength on sorption of lysozyme at different pH values. The data obtained suggested to choose desorption condition. Lytic activity of lysozyme in desorbates was evaluated using Micrococcus lysodeiktikus lyophilized cells. The results testified high recovery of lysozyme using macroreticular poly(methacrylic acid-co-acrylic acid) ter-polymeric ion-exchanger and preservation of enzymatic activity of lysozyme in desorbate.