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Publikācija: Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine

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Nosaukums oriģinālvalodā Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.3. Fizika un astronomija
Autori Marina Romanova
Jurijs Dehtjars
Anna Kačanovska
Dace Skrastiņa
Regīna Renhofa
Pauls Pumpēns
Aloizijs Patmalnieks
Atslēgas vārdi viral capsids, SiO2, nanoparticles, immunomodulation, optical absorbance
Anotācija Adherence of hepatitis B virus-like particles (VLP) to silica (SiO2) nanoparticles was explored for immunomodulation purposes. Optical absorbance measurements, transmission electron microscopy and fluorescence microscopy were employed to study the adherence. The results demonstrated that hepatitis B VLP + SiO2 complexes were formed. Preliminary immunological experiments with vaccination of Balb/c mice with the VLP only and VLP + SiO2 complexes were performed. The vaccination with VLP + SiO2 complexes resulted in increase in antibody production in mice blood. The amount of antibodies produced strongly depended on the concentration of SiO2 nanoparticles. The observed results suggest that SiO2 nanoparticles can be considered as a promising material for improving efficiency of VLP-based vaccines against hepatitis B viral disease.
Atsauce Romanova, M., Dehtjars, J., Kačanovska, A., Skrastiņa, D., Renhofa, R., Pumpēns, P., Patmalnieks, A. Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine. No: International Conference on Nanotechnologies and Biomedical Engineering (ICNBME-2011): Proceedings, Moldova, Chisinau, 7.-8. jūlijs, 2011. Chisinau: Technical University of Moldova, 2011, 344.-346.lpp.
ID 11004