Novel Synthesis of 2-Trichloromethyl-4-Vinyloxazoline and Its Derivatization by Ring Cleavage Reactions

Chemistry of Heterocyclic Compounds 2012
Liene Grigorjeva, Ansis Maļeckis, Kristīne Kļimoviča, Marija Skvorcova, Natalija Ivdra, Gundars Leitis, Aigars Jirgensons

A novel efficient and eco-friendly method for the synthesis of 2-trichloromethyl-4-vinyloxazoline is presented that involves Lewis acid-catalyzed cyclization of bisimidate derived from but-3-ene-1,2-diol. The derivatization potential of 2-trichloromethyl-4-vinyloxazoline is demonstrated by ring opening reactions with water, hydrobromic acid, hydrochloric acid, and acetic acid leading to allylamine derivatives.

Atslēgas vārdi
allyl amine, Lewis acids, oxazoline, trichloroacetimidate, cyclization
DOI
10.1007/s10593-012-1077-0
Hipersaite
http://link.springer.com/article/10.1007%2Fs10593-012-1077-0#

Grigorjeva, L., Maļeckis, A., Kļimoviča, K., Skvorcova, M., Ivdra, N., Leitis, G., Jirgensons, A. Novel Synthesis of 2-Trichloromethyl-4-Vinyloxazoline and Its Derivatization by Ring Cleavage Reactions. Chemistry of Heterocyclic Compounds, 2012, Vol.48, Iss.6, 919.-924.lpp. e-ISSN 1573-8353. ISSN 0009-3122. Pieejams: doi:10.1007/s10593-012-1077-0

Publikācijas valoda
English (en)