2,6-Diazidopurine Deoxyribo-Nucleoside as Substrate for the Click Reaction
Abstracts of Riga Technical University 55th International Scientific Conference : Section: Material Science and Applied Chemistry
2014
Dace Cīrule,
Kristers Ozols,
Ērika Bizdēna,
Irina Novosjolova
The chemistry of triazolyl-substituted purine nucleosides is attractive since some of them exhibit antiviral, anticancer or fluorescent properties.
Our group has reported the synthesis of 2,6-bistriazolyl purine arabino- and ribo-nucleosides using Cu(I) catalysed azide - alkyne 1,3-dipolar cycloaddition reaction. Various nucleophilic substitution reactions with the obtained products were carried out.
In addition to our previous work, herein we report the synthesis of the novel bis-triazolyl purine deoxyribo-nucleosides and their reactions with N- nucleophiles.
Atslēgas vārdi
Deoxyribonucleosides, "Click" chemistry
Cīrule, D., Ozols, K., Bizdēna, Ē., Novosjolova, I. 2,6-Diazidopurine Deoxyribo-Nucleoside as Substrate for the Click Reaction. No: Abstracts of Riga Technical University 55th International Scientific Conference : Section: Material Science and Applied Chemistry, Latvija, Rīga, 14.-17. oktobris, 2014. Rīga: 2014, 19.-19.lpp.
Publikācijas valoda
English (en)