A Synthetic Route for C6-Derivatization of Purine Deoxyribonucleosides

Abstracts of the Riga Technical University 56th International Scientific Conference 2015
Dace Cīrule, Kristers Ozols, Ilze Māliņa, Irina Novosjolova, Ērika Bizdēna

In last years a number of 1,2,3-triazolylnucleoside derivatives have been synthesized and investigated, leading to discovery of substances with antiviral and anticancer activity, enzyme inhibitors, adenosine receptor agonists and antagonists. Our group has reported the synthesis of 2,6-bistriazolyl purine arabino- and ribonucleosides in Cu(I)-promoted azide-alkyne cycloaddition reactions. The reactivity of products towards nucleophilic species has also been discussed. In addition to our previous work, herein we report the synthesis of the novel bistriazolylpurine deoxyribo-nucleosides and their reactions with N- and S nucleophiles.

Atslēgas vārdi
2,6-diazidopurine, 2’-deoxyribonucleosides, azide-alkyne cycloaddition, triazoles, nucleophilic substitution reaction

Cīrule, D., Ozols, K., Māliņa, I., Novosjolova, I., Bizdēna, Ē. A Synthetic Route for C6-Derivatization of Purine Deoxyribonucleosides. No: Abstracts of the Riga Technical University 56th International Scientific Conference, Latvija, Riga, 14.-16. oktobris, 2015. Riga: RTU Press, 2015, 12.-12.lpp.

Publikācijas valoda
English (en)