Hydroxyapatite (HAp) is the most frequently used mineral form for biomedical application among apatite mineral family, due to its chemical relevance to hard tissue of mammals. Chemical and structural modification of HAp have a great interest among materials scientists, practioners of medicine and dentists. In the last decade, calcium phosphate have been studied extensively for tooth remineralization, i.e., for caries preventive purpose. Strontium (Sr) and fluorine (F) co-substituted hydroxyapatite (SrFHAp) could be a good candidate or tooth enamel remineralization due to HAp structural similarity to mineral part of enamel, a long known anti-caries effect of fluorine and a potential of strontium as dentin desensitising agent. Therefore it is challenging to obtain partly co-substituted HAp with desired amount of fluorine and strontium in the apatite structure, moreover so far synthesis application of SrFHAp has not been researched for dental application.