In this work is explored biocompatibility and resorption of material made on the basis of natural hydroxyapatite (NAHp) and endodentic cement (EC). Heat treated, deproteinised NHAp is obtained from bovine bone and egg shell, two sources are chosen due to slight differences of NHAp in these raw materials. Further NAHp is combined with EC, it has quick setting, good mechanical properties and biocompatibility. However, resorption of EC differs from NHAp, so combining these two substances it is possible to get composite with good mechanical properties, quick setting time and controllable resorption, depending on concentration of components. General assumption is that fraction of NHAp resorb faster and will be formed porous structure of implant. Further into these pores ingrowth of bone can take place. Specimens of new biomaterial was implanted subcutaneous in laboratory rats and afterwards was performed histological and biocompatibility analysis, also resorption time was determined. Results have shown that new material has not caused any inflammation reaction with host tissue and progressive resorption was noted. On a basis of encouraging results we can assert that new biomaterial has potential for not load bearing bone defects healing.