Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells

Key Engineering Materials 2017
Aleksandrs Grišuļonoks, Inese Čakstiņa, Arnis Āboliņš, Jānis Ločs, Andrejs Skaģers, Ilze Šalma, Ģirts Šalms, Vadims Klimecs

To target areas of the skeletal system which are clinically significant sites is a new strategy as the"local treatment of osteoporosis". Synthetic bioceramics implanted into critical sized bone defect of rats with experimental osteoporosis demonstrateds better effect to bone tissue repair in osteoporosis and/or osteoporosis status. Stem cell transplantation may improve bone mineral density in animal models of osteoporosis. An adequate blood supply of mesenchymal cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The concentration and quality of MSCs may vary significantly, depending on the individual (especially in older people), the cell obtaining sites and techniques used. Combination of BCP and stem cells are not studied on old experimental animals with double induced osteoporosis.

Atslēgas vārdi
Biphasic calcium phosphate bioceramics, experimental osteoporosis, mesenchymal cells, bone regeneration.
DOI
10.4028/www.scientific.net/KEM.721.240
Hipersaite
http://www.scientific.net/KEM.721.240

Grišuļonoks, A., Čakstiņa, I., Āboliņš, A., Ločs, J., Skaģers, A., Šalma, I., Šalms, Ģ., Klimecs, V. Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells. No: Key Engineering Materials, Latvija, Riga, 3.-4. novembris, 2016. Switzerland: Trans Tech Publications, Switzerland, 2017, 240.-244.lpp. ISSN 1013-9826. e-ISSN 1662-9795. Pieejams: doi:10.4028/www.scientific.net/KEM.721.240

Publikācijas valoda
English (en)