Synthesis of an 8-Membered Heterocycle from Saccharin and Leakadine
Chemistry of Heterocyclic Compounds 2012
Jekaterīna Ivanova, Raivis Žalubovskis, Anatolijs Mišņovs, Igor Vozny, Gleb Kiselev

It is known that an aziridine ring can open in acidic medium in the presence of a suitable nucleophile. On the other hand, it has been reported that saccharin analogs react with oxirane to give N-hydroxyethyl-substituted saccharin derivatives. These facts allowed us to propose that a reaction of saccharin with aziridines is also possible, and this was found to be true. As a result of reaction of saccharin with 2-carbamoylaziridine (Leakadine) we have prepared the 6-oxo-3,4,5,6-tetrahydro-2H-1,2,5-benzothia-diazocine-4-carboxamide 1,1-dioxide.


Atslēgas vārdi
aziridine | Leakadine | saccharin
DOI
10.1007/s10593-012-1151-7
Hipersaite
http://link.springer.com/article/10.1007%2Fs10593-012-1151-7

Ivanova, J., Žalubovskis, R., Mišņovs, A., Vozny, I., Kiselev, G. Synthesis of an 8-Membered Heterocycle from Saccharin and Leakadine. Chemistry of Heterocyclic Compounds, 2012, Vol.48, Iss.9, 1412.-1414.lpp. ISSN 0009-3122. Pieejams: doi:10.1007/s10593-012-1151-7

Publikācijas valoda
English (en)
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