Development of Theranostic Nanosystems on the base of Amphiphilic 1,4-Dihydropyridines with Styrylpyridinium Moieties

Intrinsic Activity 2017
Klāvs Pajuste, Martins Rucins, Ludmila Jackevica, Iveta Kanepe-Lapsa, Māra Plotniece, Dace Tirzīte, Ruta Muceniece, Arkadij Sobolev, Ilona Domracheva, Kārlis Pajuste, Aiva Plotniece

The combination of diagnostic and therapeutic properties into the same agent for theranostic purposes now is focussing more and more on multifunctional nanomaterials giving 'theranostic nanoparticles'. Pyridinium amphiphiles on 1,4-DHP scaffold having self-assembling properties, capable to form liposomes can be used for DNA delivery or in perspective for drug delivery. The aim of work is the development of new nanosystems forming molecules which includes synthesis of new cationic moietiesa containing amphiphiles and evaluation of biological activities: cytotoxicity, compound-generated reactive oxygen species activity and ability to inhibit the calcium channels.

Atslēgas vārdi
amphiphilic 1,4-DHP, styrylpyridinium moiety, cytotoxicity, generated ROS activity, Ca channel anatagonis/agonist
DOI
10.25006/IA.5.S2-A2.1
Hipersaite
http://www.intrinsicactivity.org/2017/5/S2/A2.1/

Pajuste, K., Rucins, M., Jackevica, L., Kanepe-Lapsa, I., Plotniece, M., Tirzīte, D., Muceniece, R., Sobolev, A., Domracheva, I., Pajuste, K., Plotniece, A. Development of Theranostic Nanosystems on the base of Amphiphilic 1,4-Dihydropyridines with Styrylpyridinium Moieties. Intrinsic Activity, 2017, Vol.5, Suppl.2, A2.1.-A2.1.lpp. ISSN 2309-8503. Pieejams: doi:10.25006/IA.5.S2-A2.1

Publikācijas valoda
English (en)