Lipid-like Bifunctional 4-(N-Alkylpyridinium)-1,4-Dihydropyridines with Propargyl Moiety: Contribution of Molecular Structure to Cytotoxicity, Physicochemical and Self-Assembling Properties
31st Conference of The European Colloid and Interface Society (ECIS 2017): Book of Abstracts
2017
Oksana Petricenko,
Pavels Dimitrijevs,
Martins Rucins,
Ludmila Jackevica,
Anita Gulbe,
Klāvs Pajuste,
Māra Plotniece,
Marina Gosteva,
Dace Tirzīte,
Kārlis Pajuste,
Arkadij Sobolev,
Ilona Domracheva,
Aiva Plotniece
Design of delivery materials possessing biological activity is an ideal strategy for various therapies. nine 4-(alkylpyridinium)-1,4-dihydropyridine derivatives with different lengts of alkyl moieties at quaternized nitrogen atom at position 4 of the 1,4-DHP ring and with various numbers and positions of propargyl moiety/ties have been chosen for evaluation of the influence of pharmacophore group on structure-activity relationship.
Atslēgas vārdi
Lipid-like 1,4-DHP, propargyl moiety, cytotoxicity, self-assembling properties
Petricenko, O., Dimitrijevs, P., Rucins, M., jackevica, L., Gulbe, A., Pajuste, K., Plotniece, M., Gosteva, M., Tirzīte, D., Pajuste, K., Sobolev, A., Domracheva, I., Plotniece, A. Lipid-like Bifunctional 4-(N-Alkylpyridinium)-1,4-Dihydropyridines with Propargyl Moiety: Contribution of Molecular Structure to Cytotoxicity, Physicochemical and Self-Assembling Properties. No: 31st Conference of The European Colloid and Interface Society (ECIS 2017): Book of Abstracts, Spānija, Madride, 3.-8. septembris, 2017. Madride: 2017, 1.-30.lpp.
Publikācijas valoda
English (en)