Hypothesis, that optical radiation is able to alter surface electrochemical potential and due to this affect bone remod-eling processes have been proposed. Besides, researches, being done beforehand, in majority used laser radiation of single wavelength; the latter usually does not match well with optical absorption bands of the bone, obtained in a series of in–vitro experiments. The goal of the present work was to evaluate in-vivo influence of the optical light of different wavelength on the bone remodeling / reconstruction process. For this, artificial defect have been made at the mandible bone of fe-male rabbits. During operation and 10 days after surgery operation site was irradiated with optical radiation with either long (550 – 5000 nm) or short (350 – 550) wavelength. Results demonstrated that light treatment suppresses rate of healing of the bone defect for both experimental groups comparing with the control. The suppression effect is more expressed for short-wavelength irradiation